Orthopedic & Muscular System: Current Research
Open Access
ISSN: 2161-0533
+44-77-2385-9429
ISSN: 2161-0533
+44-77-2385-9429
Aparanji Poosarla and Rao D N
Andhra University, India
All India Institute of Medical Sciences, India
Posters & Accepted Abstracts: Orthop Muscular Syst
Introduction: Rheumatoid arthritis is characterized by the chronic inflammation of the synovial membrane of joints resulting cell interactions induce proinflammatory cytokine production which in turn activates the release of proteases leading to bone and cartilage destruction. Purpose of the study: Modulation of inflammatory cytokines by marine sponge products represents a possible approach to the pharmaceutical prevention and treatment of Rheumatoid arthritis. New treatments could use the effects of Th17 cells on the function of regulatory T cells. IL-17, TNF- ?±, IL-6 and IL-1 not only promote inflammation but also inhibit regulatory T cell functions. IL- 17 appears a novel target in T cell-mediated inflammatory disease, playing a role upstream in the pathologic process. Use of IL-17 inhibitors could be a way to control first inflammation but also to restore regulatory T cell functions. Methods & Materials: In our laboratory we have screened compounds purified from marine sponge collected at Andaman and Nicobar islands for anti-collagen antibody response and anti-proliferative activity using radiolabelled thymidine. We estimated the levels of IL-17, TNF-?±, IL-1?² and IL-6, IL-12, IFN-?³ from T cell culture supernatants of in vitro and in vivo compounds treated arthritic C57/black mice. In addition we also observed the IL-4 levels in the above treated mice. Results: Cytokines have been found to inhibit TH17 differentiation through various mechanisms. Both IFN- Ï? and IL-4 were recognized as suppressors of TH17 development. Conclusion: Altered balance between immunosuppressive Treg and inflammatory Th17 cells appears to be major component in disease pathogenesis.
Email: apara_p@yahoo.co.in