Clinical & Experimental Cardiology
Open Access
ISSN: 2155-9880
+44 1300 500008
ISSN: 2155-9880
+44 1300 500008
Nitin G Dumore and Monali N Dumore
Dadasaheb Balpande College of Pharmacy, India
Scientific Tracks Abstracts: J Clin Exp Cardiolog
Objective: Atherothrombosis is a disorder which may lead to increased incidence of cardiovascular diseases. One of the causes for this disorder is platelets aggregation and adhesion. Th e objective of the present study is to study eff ect of resveratrol (Resv) and clopidogrel (clopi) individually and in combination on inhibition of platelet aggregation and adhesion by in vitro and in vivo method. Material & Method: Th e platelet aggregation was measured by whole blood aggregometer (Chronolog Corporation) in 0.5 ml sample of PRP mixed with ADP by measuring infrared light transmission using diff erent concentration of resveratrol and clopidogrel individually and in combination. Platelet adhesion was measured by Microplate reader, lab system (Merck Pvt. Ltd.). Nitric oxide estimation was done by nitric oxide colorimetric estimation kit with retro orbital method using healthy male Swiss albino rats. Result: Resveratrol and clopidogrel at the eff ective concentration produced minimal platelet aggregation and adhesion eff ect, when combined together didn�¢����t show any synergistic or additive eff ect. Th ere was no eff ect of resveratrol on clopidogrel or vice versa on their inhibitory eff ect. Both individually and in combination increased bioavailability of nitric oxide revealed the signifi cant (P<0.05). Conclusion: Since patients on antiplatelet therapy may consume beverages like grape juice, red wine, peanuts etc., which are rich sources of resveratrol do not show any synergistic or additive eff ect on platelet function. But increased bioavailability of nitric oxide leads to adverse outcome.
Nitin G Dumore is currently pursuing his PhD from RTMNU Nagpur University in India. He has completed his MPharmacy in Pharmacology. Presently he is working as the Principal at Dadasaheb Balpande College of Pharmacy in Nagpur, India. He has published more than 10 papers in reputed journals.