Journal of Developing Drugs
Open Access
ISSN: 2329-6631
+44 1478 350008
ISSN: 2329-6631
+44 1478 350008
Noha S El-Salamouni
Pharos University in Alexandria, Egypt
Posters & Accepted Abstracts: J Develop Drugs
Nanoparticulate delivery systems have recently been under consideration for topical ophthalmic drug delivery. Brimonidine baseloaded solid lipid nanoparticles and nanostructured lipid carrier formulations were prepared using glyceryl monostearate as solid lipid and were evaluated for their physical stability following sterilization by autoclaving at 121�°C for 15 minutes. The objective of this work was to evaluate the effect of autoclaving on the physical appearance, particle size, polydispersity index, zeta potential, entrapment efficiency and particle morphology of the prepared formulations, compared to non -autoclaved ones. Results showed that, autoclaving at 121�°C for 15 minutes allowed the production of physically stable formulations in nanometric range, below 500 nm suitable for ophthalmic application. Moreover, autoclaved samples appeared to be superior to non -autoclaved ones, due to their increased zeta potential values, indicating a better physical stability. As well as, increased amount of brimonidine base entrapped in the tested formulations.
Email: noha.soliman@pua.edu.eg