Journal of Developing Drugs
Open Access
ISSN: 2329-6631
+44 1478 350008
ISSN: 2329-6631
+44 1478 350008
Heba Nassar, Mohammad Farouk, Riham Hussein and Tamer Fathy
Cairo University, Egypt
Posters & Accepted Abstracts: J Develop Drugs
Aim: This double-blinded, randomized, controlled study was designed to explore and compare the possible effects of nalbuphine on the clinical profile of levobupivacaine-induced caudal block in children undergoing lower abdominal surgeries. Materials & Methods: The study included 40 patients (1ΓΆΒ?Β?9 years) randomised to receive 1ml/ kg levobupivacaine 0.25% plus 0.5 ml normal saline (control(L) group n=20) or 1ml/ kg levobupivacaine 0.25% plus 0.5 ml nalbuphine (0.1 mg/kg) (nalbuphine (LN) group n=20) after induction of anaesthesia. All patients received a standard anaesthetic including: sevoflurane induction, Isoflurane maintenance, and patients were breathing spontaneously. The primary outcome was time to first request for rescue postoperative analgesia. Haemodynamic changes, objective sedation score based on eye-opening and AIIMS pain discomfort scale (All India Institute of Medical Sciences); were recorded at predetermined intervals. Results: Patients characteristics were comparable in the two groups. The time to first request to rescue analgesic was longer in the nalbuphine group compared to the control; 11.2 (1.6), 5.9 (1.0) h, respectively (P<0.01). AIIMS pain score was significantly higher in the control group at 4, 6 and 12 hours postoperatively; while the nalbuphine group had higher sedation scores at 30 min and 1 hour post-operatively. Haemodynamics were comparable in the two groups and nalbuphine use was not associated with any observed side effects. Conclusion(s): Nalbuphine as adjuvant to levobupivacaine induced caudal analgesia is safe in children undergoing lower abdominal surgeries and prolongs duration of postoperative analgesia. However it may cause early postoperative sedation, yet without respiratory depression.
Email: hebanassar01@yahoo.com