Immunotherapy: Open Access
Open Access

Efficacy of Zhu Ling Polyporus polysaccharide with BCG to inhibit bladder carcinoma

International Conference on Tumor & Cancer Immunology and Immunotherapy

July 28-30, 2016 Melbourne, Australia

Guo-wei Zhang

Hebei University, China

Posters & Accepted Abstracts: Immunother Open Acc

Abstract :

There is growing interest in reducing Bacillus Calmette-Guerin (BCG) side effects while keeping intact its therapeutic efficacy. In the present study, we evaluated the efficacy of Sclerotia of Polyporus umbellatus FRIES (Zhu Ling) and its main ingredient Polyporus Polysaccharide (PPS) to attenuate side effects of BCG therapy in vivo. The results show that bladder cancer development in model rats exhibited significantly reduced cancer invasiveness with Zhu Ling PPS combined with BCG. Flow cytometric (FCM) analysis showed expression of co stimulatory molecules CD86, CD40 and TLR4/CD14 significantly increased with Zhu Ling PPS in combination with BCG. Similarly, immune-histochemical analysis revealed stronger CD86 and CD40 staining. Our findings show Zhu Ling PPS strongly reduced side effects and displayed synergistic effects during BCG instillation in rat bladder cancer models. The findings also suggest that the attenuation effect may result from direct activation of dendritic cell (DC) TLR4.

Biography :

Email: xxzgw@126.com