Journal of Chromatography & Separation Techniques
Open Access
ISSN: 2157-7064
+44 1300 500008
ISSN: 2157-7064
+44 1300 500008
Katsuhiro Maeda
Kanazawa University, Japan
Scientific Tracks Abstracts: J Chromatogr Sep Tech
Separation of enantiomers by high-performance liquid chromatography (HPLC) is an effective method both for analyzing enantiomer composition of chiral compounds and obtaining pure enantiomers. Although a large number of chiral stationary phases (CSPs) for HPLC have been developed, it is still a challenging issue to switch the elution order of enantiomers under identical chromatographic conditions. Recently, we have found that a polyacetylene derivative bearing 2,2ΓΆΒ?Β?-biphenol-derived pendants can form a preferable helical conformation in response to the chirality of non-racemic guest compounds, such as 1-phenylethanol (PEA), in the solid state as well as in solution, and the induced preferred-handed macromolecular helicity can be maintained, that is memorized, even after complete removal of the chiral guests. By taking advantage of this unique feature, we have succeeded in developing an unprecedented switchable CSP for HPLC, in which the elution order of the enantiomers can be switched, which will be based on reversible switching and subsequent memory of the macromolecular helicity by the treatment with (R)- and (S)-PEA in the solid state. In order to improve the chiral recognition ability, we synthesized analogous polyacetylene derivatives with ester or carbamate groups as the effective interaction sites and investigated a relationship between the structures of the pendants and the recognition abilities of the polymers. Repetitive switching of the elution order of enantiomers based on the switching of the macromolecular helicity was achieved by immobilizing these polymers onto silica support.
Katsuhiro Maeda has received his BS (1993), MS (1995) and PhD (1998) degrees from Nagoya University. In 1998, he joined the Graduate School of Molecular Design and Engineering, Nagoya University, as an Assistant Professor and was promoted to an Associate Professor in 2002. He moved to Kanazawa University in 2008 and was appointed as a Full Professor in 2015. He has published more than 80 original papers in various reputed journals.
Email: maeda@se.kanazawa-u.ac.jp