Pediatrics & Therapeutics
Open Access

Endothelial function evaluation in patients with anorexia nervosa

International Conference and Exhibition on Pediatric Cardiology

August 25-27, 2015 Valencia, Spain

Rubin S Cooper1, Patcharapong Suntharos2, Myriam E Almeida-Jones3, Howard S Seiden4, Martin Fisher5, Dorota Gruber5, Lisa M Rosen1 and Andrew D Blaufox1

5North Shore-Long Island Jewish Health System, USA 2Cleveland Clinic Children�s Hospital, USA 3University of California, USA 4Kravis Children�s Hospital at Mount Sinai, USA 5Steven and Alexandra Cohen Children�s Medical Center of N

Posters-Accepted Abstracts: Pediat Therapeut

Abstract :

Introduction: This study evaluated endothelial function in patients with anorexia nervosa (AN) using Endothelial Pulse Amplitude Testing (Endo-PAT) and correlated findings with the patients� history and biochemical data. Method: Twenty-one patients age 13-21 years diagnosed with AN by the Division of Adolescent Medicine at Cohen Children�s Medical Center of NY between 6/1/2012 and 5/31/2013 were studied along with 19 healthy controls similar in age and gender distribution. Digital pulse amplitude was examined using Endo-PAT. Raw data were automatically transferred into a reactive hyperemia index (RHI) and the natural log transformation of RHI (LnRHI). Subjects� and controls� electrocardiograms and biochemical markers were obtained. Results: AN and controls had similar RHI (P=0.75) and LnRHI (P=0.95). AN had lower mean weight (P<0.001), height (P=0.02), BMI (P<0.001), resting HR (P<0.001), systolic (P<0.001) and diastolic BP (P=0.01). AN also had lower mean HR during EndoPAT testing (P<0.001), triiodothyronine (T3) (P<0.001), luteinizing hormone (LH) (P=0.006) and estradiol (E2) (P=0.005). Total cholesterol (Chol) (P<0.001) was higher in AN subjects. No correlation was observed between RHI and other parameters. Conclusion: No significant differences in RHI or LnRHI found between the two groups. There were significantly higher Chol and lower HR, T3, LH and E2 levels in the AN group compared to controls. There were no correlations of these parameters to RHI.

Biography :

Rubin S Cooper, MD Specialty is Pediatric Cardiology, Pediatrics. He is a Chief - CCMC Division of Pediatric Cardiology and Professor, Hofstra North Shore-LIJ School of Medicine, USA.

Email: RCOOPER3@NSHS.edu