Journal of Clinical Toxicology
Open Access
ISSN: 2161-0495
+44 1478 350008
ISSN: 2161-0495
+44 1478 350008
Padmapriya Baliiepalli
Posters: J Clinic Toxicol
I midacloprid is a neonicotinoid insecticide with neurotoxic action. Only few data is available on its toxicity for aquatic species. Imidacloprid considered as possible replacement for the widely used organophosphate pesticides. However, limited researchers have made to study imidacloprid genotoxic effect in different fish tissues. The present investigation was aimed to assess the evaluation of the genotoxicity of the insecticide to the fresh water teleost Channa punctatus using Comet assay. The fishes were exposed to five concentrations (0.002, 0.004, 0.006, 0.008 and 0.01 ppm) for 96 h and sampling was done at regular (24, 48, 72 and 96 h) intervals for assessment of DNA damage in gill tissue. A noticeable rise in gill DNA break up has been observed in exposed fishes. This study recommends the use of comet assay as a tool to screen genotoxicity in aquatic fauna on exposure to xenobiotics.