Pediatrics & Therapeutics
Open Access

Evolution in congenital heart defects surgery since Gibbon first closed an ASD using cardiopulmonary bypass: “Personalized repairs”

International Conference and Exhibition on Pediatric Cardiology

August 25-27, 2015 Valencia, Spain

L Ben Mime

Heart and Diabetes Center NRW, Germany

Posters-Accepted Abstracts: Pediat Therapeut

Abstract :

Anatomical era: Recognizable patterns of normal and pathological anatomy; restoration of functional anatomy, ASD, VSD closures; Total abnormal venous drainage; valve repair; Dacron conduits. Pathophysiologic era: Increased understanding of cardiac physiology; emphasis on physiologic goals, staged procedures, Fontan principle. Valve prosthetic replacements; Shunts for cyanotic lesions; Bypass grafts, conduits, Homografts. Biochemical and technological era: Increased understanding and incorporation into surgical tactics of the biochemistry of myocardial metabolism, ventricular biomechanics, and applied technologies, e.g. improved CPB circuitry; material development and improved prosthetic heart valves based on engineering design principles; improved imaging, single stage neonatal/infant repairs, minimizing staging and palliation. 3rd generation valve replacement; aortic root replacements; 80% cardiac repairs <12 months of age; hypoplastic left heart staged repairs. Regenerative surgery era: Viable replacement constructs molecular and genetic therapies incorporated into surgical repairs: bioengineering, tissue engineering, cell and gene therapies, regenerative medicine, molecular therapies, â�?�?Personalizedâ�? repairs, e.g. Tetralogy of Fallot reconstruction with growth capable RVOT and pulmonary artery viable tissue conduits. This revolution will require a combination of expertiseincluding cell and molecular biology, tissue engineering, surgery, tissue mechanics, cell signaling, chronic animal modeling.

Biography :

Email: LBen-Mime@hdz-nrw.de