Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
+44 1223 790975
ISSN: 0974-276X
+44 1223 790975
Sompop Bencharit
Scientific Tracks Abstracts: J Proteomics Bioinform
Saliva is a collection of fluid from salivary glands, gingiva, oral tissues, and upper respiratory tract. The non-invasive nature of sample collection and the highly abundant protein composition of saliva may in the near future allow development of diagnostic tools for various diseases from oral to systemic disease. The components of salivary proteomes are similar to those of plasma proteomes. Changes in salivary proteomes therefore theoretically reflect both oral and systemic changes. We will review the current stage of salivary proteomic studies. Sample collection methodology, subject selection, mass spectrometry techniques, and discovered biomarkers will be reviewed. Limitations and recommendations will be discussed. We will discuss the case studies exploring the salivary proteomes in 1) oral candidiasis associated with wearing dentures, 2) opportunistic infections associated with HIV-infection, and 3) type 1 and 2 diabetes. Salivary proteomics provides a novel state-of-the-art approach to new biomarker discovery and, in the near future, to saliva-based diagnostic tools.
Sompop Bencharit is a Diplomate of the American Board of Prosthodontics and a Fellow of the American College of Prosthodontists. He is one of very few clinician-scientists who are both board-certified dental clinicians and PhD scientists. Dr. Bencharit currently serves as Journal Editor for Stem Cells in Oral Medicine. He has his research interests in structural biology and its applications to human diseases in particular the role of signaling proteins involved in vessel and bone development. In addition, he is also interested in the clinical applications of salivary, cellular, and tissue proteomics using advanced mass spectrometry.