Journal of Clinical & Experimental Dermatology Research
Open Access

Extramammary Paget Disease Secondary to Urothelial Carcinoma; A Case Report

21^st European Dermatology Congress

July 12-13, 2021 | Webinar

Gyoo Huh

Sungkyunkwan University School of Medicine, Korea

Scientific Tracks Abstracts: JCEDR

Abstract :

Extramammary Paget disease (EMPD) is a rare adenocarcinoma which can be primary or secondary to an underlying malignancy. 20-30 % of patients are estimated to associated with visceral malignancy. Secondary EMPD is most commonly extended from anorectal or urothelial carcinoma. When the lesion involves perianal or periurethral area, a thorough search for internal malignancies should be performed. Immunohistochemistry (IHC) is necessary to differentiate between primary and secondary disease. We report a case of a 71-year-old male with EMPD secondary to urothelial carcinoma. He presented with 8-month history of erythematous patch on urethral meatus. The lesion was diagnosed with herpes viral infection 6-months ago. It had not shown improvement since he treated with antiviral therapy. He has medical history of urothelial carcinoma of bladder for which he had radical cystectomy 3-years ago. Histopathologic fi ndings demonstrated pagetoid cells in the epidermis. IHC staining showed positive for CK 7, CK 20 and CAM 5.2, but negative for S-100. The patient was diagnosed with secondary EMPD with an underlying urothelial carcinoma. The lesion was managed with urethrectomy and partial penectomy. There is no sign of recurrence after a month of treatment.We recommend that careful evaluation of skin lesion on periurethral area should be done when the dermatologists encounter with the patient who had history of urothelial carcinoma.

Biography :

Huhgyoo graduated School of Medicine, Yonsei University He has worked as reident in Kangbuk samsung hospital, Sungkyunkwan University School of Medicine, Department of Dermatology since 2019