Journal of Pharmaceutical Care & Health Systems
Open Access
ISSN: 2376-0419
+44 1300 500008
ISSN: 2376-0419
+44 1300 500008
Mori Dhavalkumar
B K Mody Government Pharmacy College, India
Posters-Accepted Abstracts: J Pharma Care Health Sys
The aim of the present investigation is to prepare and optimize pulsatile release, time specific delivery system for the thiocolchicoside which is used for treatment of lower back pain (orally 4-8 mg two to three times a day). The basic design consists of making a core tablet containing thiocolchicoside and Sodium Starch Glycolate (SSG) as super-disintegrant which can give instant release and compression coated with various proportions of Eudragit S100 and Ethyl Cellulose (EC) to prevent the release before intended period (6 hours). 32 full factorial design was used to optimise the formulation in which amount of SSG in the core and amount of Eudragit S100 and EC in coat were taken as independent variables. The results of in-vitro study indicates that tablets successfully retards the release of drug up to 6 hours and after that more than 90% drug get released in 30 min. The results of the optimized batches� release patterns were similar to predicted release pattern. Programmable pulsatile release has been achieved by compression coating technique, which coincide with predetermined specification required for chronotherapeutic drug delivery.
Email: moridhaval@gmail.com