Journal of Pharmaceutical Care & Health Systems
Open Access
ISSN: 2376-0419
+44 1300 500008
ISSN: 2376-0419
+44 1300 500008
Amit Sharma
I S F College of Pharmacy, India
ScientificTracks Abstracts-Workshop: J Pharma Care Health Sys
Malaria is a serious endemic disease in many parts of the world, affecting 5% of the worldâ��s population. About 40% of the worldâ��s population is at stake of malaria. Arteether is a well known antimalarial mainly used in the treatment of cerebral malaria as well as chloroquine resistance malaria. But the main problems associated with arteether are its low solubility (â��17 �¼g/ml) and â��40 % degradation in stomach. Due to these limitations, arteether is available only as intramuscular injection. The aim of present study is to formulate the colon targeted matrix tablets for improvement of colonic bioavailability of arteether by enhancing the solubility with cyclodextrin inclusion complex and preventing its degradation in stomach. Inclusion complexes of arteether with �²-cyclodextrin in 1:1 molar ratio were prepared by techniques like co-evaporation and spray drying. The prepared complexes were characterized by using H-NMR, FTIR, differential scanning calorimetry, mass spectroscopy and PXRD. Complexation with �²-CD in co-evaporation technique showed the maximum enhancement in solubility, i.e., 77.05 folds, in presence of PVP. This complex with better properties was further selected for preparation of colon targeted matrix tablets to prevent the degradation of arteether in stomach with improved solubility and better colonic bioavailability.
Amit Sharma has completed his Master’s degree from Rajiv Gandhi University of Health Sciences, Karnataka and is doing PhD from Uttrakhand Technical University. He is the Head, Department of Pharmacy Practice, I S F College of Pharmacy, Moga. He has published more than 13 papers in reputed journals and is serving as an Editorial Board Member of repute.
Email: choice.amit@gmail.com