Journal of Clinical & Experimental Dermatology Research
Open Access

Fractal dimension of transdermaldelivery drug models: 4-alkylanilines

International Conference & Exhibition on Clinical Research Dermatology, Ophthalmology & Cardiology

5-6 July 2011 San Francisco, USA

Francisco Torrens

Scientific Tracks Abstracts: JCEDR

Abstract :

The pathways that exist in porous membranes used to deliver drugs form fractal percolating paths. For a homologous series of 4- alkylanilines, the fractal dimension D is calculated as a model for transdermaldelivery drugs. Program TOPO is used for the calculation of the solvent-accessible surface AS, which is denoted by the centre of a probe, which is allowed to roll on the outside while maintaining contact with the bare molecular surface S . AS depends on the probe radius R . For 4-alkylanilines, the quadrupole moment ı is doubled. The hydrophobic contribution to AS is doubled while its hydrophilic part remains constant. D increases 11%. Geometric descriptor and topological index results are in agreement with reference calculations. The 1-octanol? water partition coefficient log P increases. The molar concentration of organic compounds necessary to produce a 1:1 complex with bovine serum albumin via equilibrium dialysis, log1/ C increases. The hydrophile?lipophile balance (HLB) decreases. The linear correlation between D and ı, and non-linear correlations between D , log P , log1/ C and HLB point to a homogeneous molecular structure of the 4-alkylanilines. The comparison with phenyl alcohols shows that their greater dipole moments cause lower hydrophobicity.