Journal of Clinical & Experimental Dermatology Research
Open Access
ISSN: 2155-9554
+44 1478 350008
ISSN: 2155-9554
+44 1478 350008
Amir Feily
Jahrom University of Medical Sciences, Iran
Posters & Accepted Abstracts: J Clin Exp Dermatol Res
Background: Fractional CO2 laser and autologous hair transplantation are independently effective in the treatment of refractory and stable vitiligo. Objective: The authorâ??s purpose was to evaluate the therapeutic efficacy of fractional CO2 laser pretreatment compared with autologous hair transplantation and phototherapy alone for refractory and stable vitiligo. Methodology: A total of 20 patients with refractory and stable vitiligo were enrolled from our clinic. Resistant lesions randomly divided into 2 regions as follows: (1) Part A: Fractional CO2 laser pretreatment followed by autologous transplantation and phototherapy and (2) Part B: Autologous transplantation and phototherapy alone. Five days after fractional CO2 laser application to Part A, both treatment regions received a transplant of scalp grafts. On day 11, the entire lesion was exposed to narrow-band UVB phototherapy, twice a week for 12 weeks. The diameter of perifollicular repigmentation was measured monthly with a caliper. Results: Perifollicular repigmentation was detectable surrounding 74% of grafted hair follicles by month 3. Furthermore, Part A demonstrated a significantly greater diameter of repigmentation with 6.6ï?±5.8 mm in Part A compared with 4.3ï?±1.8 mm in Part B (pâ?¤0.001). Conclusion: In this study, our results demonstrate improved efficacy of autologous hair transplantation and narrow-band UVB with fractional CO2 laser pretreatment in refractory and stable vitiligo.
E-mail: dr.feily@yahoo.com