Clinical & Experimental Cardiology
Open Access

Gender difference in ischemic heart disease

16^th World Cardiology Congress

December 08-10, 2016 Dubai, UAE

Olivia Manfrini

University of Bologna, Italy

Posters & Accepted Abstracts: J Clin Exp Cardiolog

Abstract :

Scientific interest in ischemic heart disease (IHD) in women has grown over the past two decades. A substantial amount of the literature on this subject is centered on sex differences in clinical aspects of IHD. Many reports have documented sex-related differences in presentation, risk profiles and outcomes among patients with IHD, particularly acute myocardial infarction. Such differences have often been attributed to inequalities between men and women in the referral and treatment of IHD. The determinants of sex differences in presentation are unclear. Some evidences are available as to why young, premenopausal women paradoxically have a greater incidence of adverse outcomes after acute myocardial infarction than men, despite having less-severe coronary artery disease. Other study underline possible difference in the coronary anatomy (women often have more severe microvascular dysfunction), and in pathophysiological causes for chronic and acute presentation of IHD. Differential treatment on the basis of patient sex continues are described. The extent to which such inequalities persist and whether they reflect true disparity is under scrutiny. Additionally, much uncertainty surrounds possible sex-related differences in response to cardiovascular therapies, partly because of a persistent lack of female-specific data from cardiovascular clinical trials.
Recent Publications:
1. Cenko E, Ricci B, Kedev S, Vasiljevic Z, Dorobantu M, Gustiene O, Kne�?¾evi�?�? B, Mili�?i�?�? D, Dilic M, Manfrini O, Koller A, Badimon L and Bugiardini R (2016) Invasive versus conservative strategy in acute coronary syndromes: The paradox in women's outcomes. Int J Cardiol 222:1110-5.
2. Ricci B, Cenko E, Varotti E, Puddu PE and Manfrini O (2016) Atypical chest pain in ACS: A trap especially for women. Curr Pharm Des. 22:3877-84.
3. Vaccarino V1, Badimon L, Corti R, de Wit C, Dorobantu M, Manfrini O, Koller A, Pries A, Cenko E and Bugiardini R (2013) Presentation, management and outcomes of ischaemic heart disease in women. Nat Rev Cardiol 10:508-18.

Biography :

Email: olivia.manfrini@unibo.it