Journal of Clinical Toxicology
Open Access

Genotoxicity of gemcitabine low dose in white rat bone marrow cells

9^th Euro-Global Summit on Toxicology and Applied Pharmacology

June 22-24, 2017 Paris, France

Abdul Rahman A I Alyahya

Shaqra University, Saudi Arabia

Posters & Accepted Abstracts: J Clin Toxicol

Abstract :

Gemcitabine is a modern chemical drug used widely against many serious diseases including advanced cancers such as lung cancer, bladder and ovarian cancers a several blood cancers. Gemcitabine is one of the preferred choices in the treatment of pancreatic cancer. A short-term test was conducted and the drug showed rapid and strong ability to detect toxicity or distorting the material studied in the neighborhood cells. Results showed that there are some changes in cell parameters which can be determined by cellular examination accurately. Exposing male inbred line SWR/J of laboratory mice to low dose of the drug (125 mg/kg) Gemcitabine individually and in combination affected significantly in different times intervals mitotic divisions and chromosomal aberrations and abnormalities. The severity of abnormalities was increased with the passage of treated time.

Biography :

Email: alya7ya@su.edu.sa