Journal of Infectious Diseases & Preventive Medicine
Open Access
ISSN: 2329-8731
+44 1300 500008
ISSN: 2329-8731
+44 1300 500008
Swapna Amod Patankar
Bharati Vidyapeeth Deemed University, India
Received: September 17,2021; Accepted: September 20,2021; Published:February 07,2022
Scientific Tracks Abstracts: J Infect Dis Preve Med
Aim: To detect presence of HPV genotypes in the saliva samples of HIV sero-positive patients. Objectives: 1. To detect presence HPV genotypes in the saliva samples of HIV sero-positive patients. 2. To detect presence of any oral lesions or oral cancers in the oral cavity of these HIV sero- positive patients. 3. To evaluate if there is any co-relation between the HPV genotypes if present & oral lesions or oral cancers is present in the oral cavity. Introduction: Human Papilloma Virus (HPV) is a small circular double stranded DNA virus which has been implicated in a variety of benign and malignant neoplasias in human oral and anogenital regions. About 100 different HPV genotypes have been identified and classified as either low-risk or high-risk oncogenic types based on their ability to induce neoplasia in host epithelial cells. Most prevalent high-risk types are HPV 16 and 18, which have been detected in the majority of malignant lesions worldwide. Low-risk types such as HPV 6 and 11 are most often associated with benign lesions. Several epidemiological and molecular studies have suggested a significant link between high-risk HPV types (mainly 16 and 18) and oral cancer. Recent evidence has indicated that HPV-related pathology is increased in the oral cavity of Human Immunodeficiency Virus give (HIV)-positive individuals. HPV types are known to be seen more in HIVpositive patients, as they are immune-deficient. HPV in saliva of HIV-positive individuals may be associated with high risk for development of HPV-related oral lesions, including malignancy. Methods: To detect the presence of HPV in HIV-positive patients, 30 saliva samples of sex- workers from redlight street areas in Pune were collected & DNA sequences carried out by polymerase chain reaction (PCR). Results: The results obtained were negative for HPV in the 30 saliva samples. Thus, indicating that more sample size should be considered for detection of HPV in HIV sero-positive patients for detection of HPV in saliva samples. Conclusion: This is a non-invasive & prognostic type of study, the results of which will defiantly help in screening, early detection & prevention of HPV related oral cancers in immune-compromised HIV patients by using saliva samples.
Swapna Amod Patankar is an Assistant Professor (MDS) in the Department of Oral & Maxillofacial Pathology & Oral Microbiology at Bharati Vidyapeeth (Deemed to be University) Dental College & Hospital, Pune, India. She is currently pursuing PhD in the Faculty of Dentistry. She has an academic teaching experience of 20 years 10 months. She has carried out numerous research projects & has extensive research work on the HIV sero-positive individuals. She has numerous national & international publications to her credit & has also published 2 international books.