Journal of Hepatology and Gastrointestinal disorders
Open Access

Hepatotoxicity and related risk factors of severe hepatotoxicity among HIV-1 infected Individuals initiated on highly active antiretroviral therapy in Cameroon

27^th World Congress on Diet, Nutrition and Obesity & 18^th World Gastroenterologists Summit

September 07-08, 2018 Auckland, New Zealand

Lem Edith Abongwa, Anthony KebiraNyamache, Fokunang Charles, Judith Torimiro, Nshom Emmanuel , Irenee Domkam and Paul Okemo

University of Bamenda, Cameroon
Kenyatta University, Kenya
Chantal Biya International Center for Research on the Prevention and Management of HIV/AIDS, Cameroon
University of Yaounde I, Cameroon
Mbingo Baptist Hospital, Cameroon

Posters & Accepted Abstracts: J Hepatol Gastroint Dis

Abstract :

Aims: Hepatotoxicity due to highly active antiretroviral therapy (HAART) has gained prominent attention since it can be affected by many factors. The aim of this study was to determine the prevalence of hepatotoxicity and related risk factors of severe hepatotoxicity following HAART initiation. Methods: 100 naive HIV-1 patients were recruited and followed up for 24 weeks. They were placed on either Tenofovir(TDF) + Lamivudine(3TC) + Efavirenz (EFV) or Zidovudine(AZT) + Lamivudine + Nevirapine (NVP) or Zidovudine+Lamivudine+Efavirenz regimen. Venous blood samples were collected to measure transaminotransferases (ALT and AST) and Alkaline Phosphatase (ALP), using colometric enzymatic reaction which were used to classified hepatotoxicity based on age and sex. Results: A total of 38% and 55% patients presented with hepatotoxicity while 15% and 28% of patients of them had severe hepatotoxicity at 4 and 24 weeks, respectively. Serum levels of all enzymes increased significantly (p<0.05) with increased treatment duration. Univariate analysis revealed that the risk factor of developing severe hepatotoxicity was significantly (p<0.05) greater in patients <30 years, males, low BMI, low monthly income earners and patient on AZT+3TC+ NVP regimen. While multivariate analysis showed that age <30 years, Low BMI, low monthly income and the use of AZT+3TC+NVP was an independent risk factors. Conclusions: Low BMI, <30years, low monthly income and the use of AZT+3TC+NVP regimen were identifiable risk factors for the development of severe hepatotoxicity. As such these factors should be considered as an important strategy by clinicians in preventing the hepatotoxicity

Biography :

E-mail: lemedith19@gmail.com