Clinical & Experimental Cardiology
Open Access
ISSN: 2155-9880
+44 1300 500008
ISSN: 2155-9880
+44 1300 500008
Ayu Aprilia Citra, Ninditasari Ghina and Waluyo B R Djoko
University of Pembangunan Nasional â??Veteranâ?, Indonesia
Posters & Accepted Abstracts: J Clin Exp Cardiolog
Background/Aims: Higher cost and side effects that are made by some anti-cholesterol drugs which used in long time is the reason why some people change to herb therapy. One of the herbs is Tamarindus indica (Tamarind) leaves. This research aims to determine hypolipidemic effect and antioxidant activity of extract of Tamarind Leaves (ETL). Methods: Samples used were 25 rats, divided into 5 groups: Negative control (CMC 0.5%), positive control (Ezetrol (Ezetimibe 1.26 g/KgBW)), ETL 1st, 2nd, and 3rd dose in a row 0.93 g/KgBW, 1.86 g/KgBW and 3.73 g/KgBW. Results: Paired-samples T-test showed ETL significantly lower total cholesterol (TC) and triglyceride (Tg) level when compared to both of control groups (p<0.05), but Low-density Lipoprotein Cholesterol (LDL-C) and High-density Lipoprotein Cholesterol (HDL-C) level had no significant difference (p>0.05). TC level also were analyzed with Kruskal-Wallis test, Tg and LDL-C level were analyzed with one-way ANOVA test. ETL exhibited the significant reduction between groups (p<0.05), but Tg and HDL-C level had no significant difference (p>0.05). Furthermore, the data of TC level were analyzed with Post Hoc test and there was a significant difference between both of control group and all variance ETL doses (p<0,05); In LDL-C level had a significant difference between both of control group, ETL 1st and 2nd Dose. For antioxidant activity, Malondialdehyde (MDA) level between pre and post intervention had significant difference (p<0.05). Furthermore, the data were analyzed with one-way ANOVA test, but ETL exhibited no significant difference in MDA and Superoxide Dismutase (SOD) level (p>0.05). Conclusion: All ETL doses have hypolipidemic effect and antioxidant activity. ETL also has similar effect with ezetimibe. Saponin, flavonoid, and tanin that contained likely contribute to these pharmacologic effects.
Email: citraayuaprilia@gmail.com