Virology & Mycology
Open Access
ISSN: 2161-0517
ISSN: 2161-0517
Vivek Chandramohan, Manjunath Dammalli and Gowrishankar B S
Posters-Accepted Abstracts: Virol-mycol
Objectives: To find alternative drug for the treatment of pandemic disease caused by influenza virus. Methods: The structure based drug design approach was employed. New sequence was employed to build the N1 simulation structure by homology modeling which was further checked for high reliability by verify score and Ramachandran plot. Drug likeness and ADMET evaluation showed that the Ligands satisfy all the properties to be used as a drug. Docking studies were performed using LeadIT and docking scores indicated good binding energy values towards N1. Results: Best lead compounds were screened and suggested as potent target candidates from thedocking studies. The screened compounds from Camellia sinensis family illustrated better activity compared to the drugs which are already present in the market. Conclusion: The results may help to find the alternative drug to solve the drug-resistant problem and stimulate designing more effective drugs against (A/chicken/India/CA0301/2011(H5N1)) influenza pandemic, yet pharmacological studies have to confirm it.