Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
ISSN: 0974-276X
Zeeshan Iqbal, Jawaria Munir and Nasir Uddin
Institute of Molecular Sciences & Bioinformatics, Pakistan
Scientific Tracks Abstracts: J Proteomics Bioinform
Urogenital tract in human body is colonized with various types of microbial species that aid to maintain the functional environment and prohibit growth of pathogenic species. The proteins in urogenital microbiome are the major elements to perform various biological functions. The Metaproteome of urogenital microbiota can perform multiple functions by interacting with human proteins. The functional diversity can arise due to structural modification of functional group in human and/or microbiome proteins. At molecular level, host-microbiome interface involves protein-protein interactions (PPIs) and this interaction is associated with a variety of biological functions. Post-translational modifications (PTMs) on proteins are also critical for the regulation of various functional activities and these modifications are controlled by environment of the proteins and the surrounding amino acids of the modified residues. In this study, structural and functional changes in urogenital metaproteome and human proteins have been examined. For the sequence analyses of the surrounding amino acids of modified residues on the bases of biophysical and biochemical properties of the amino acids, a computational tool named as MAPRes (Mining Association Patterns Among Preferred Amino Acid Residues in the Vicinity of Amino Acids Targeted for Post-translational Modifications) were brought into account. By utilizing MAPRes and other computational tools, The Metaproteomic analyses were performed to understand mechanism of urinary tract infections (UTI).
Zeeshan Iqbal has completed his Post graduation from GC University, Lahore, Pakistan. He is the Senior Research Associate at Institute of Molecular Sciences and Bioinformatics, Lahore, a premier Bioinformatics research institute of state. He is working as a Senior Software Application Engineer. He is also teaching in GC University, Lahore as Visiting Lecturer. He has published 14 papers in reputed journals and serving as an Editorial Board Member of various journals. He has good skills in algorithm writing, modeling and simulation of different scientific problems not only in life sciences but also in the field of applied physics and chemistry.
Email: zeeshaniqbal3506@yahoo.com