Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Ana Laura Pelayo GÃ?³mez, Lorena MartÃ?Ânez Alcantar, Diana Karina Talavera Carrillo, Jonhatan Uriel Pineda Salazar, Dra Alma Lilia Fuentes, FarÃ?Âas y Dra and Esperanza MelÃ?©ndez Herrera
Michoacan University of San Nicolas de Hidalgo, M�©xico
Posters-Accepted Abstracts: J Clin Cell Immunol
The eye is able to regulate the inflammatory response by activating a specific and systemic tolerance to antigens that are inoculated within it. This ability can be exploited to regulate the inflammatory response in degenerative diseases. A great number of neurodegenerative diseases occur with a primary or secondary inflammation as a homeostatic mechanism to monitor and repair tissue. Among the main negative effects of chronic inflammation include inability to repair tissue and the establishment of an autoimmune response that helps to extend the injury. Thus, adequate regulation of antigen-dependent inflammatory response through the establishment of immune tolerance could be an efficient mechanism to restrict the injury and promote tissue repair in degenerative diseases. However, the time during which this state of immuno-tolerance is maintained and whether its permanence depends on the age of induction is unknown to this date. The aim of the present work is to evaluate the persistence of immuno-tolerance to neural auto-antigens, inoculated in the anterior chamber of the eye. The rats were subsequently immunized with the same antigens to assess specific immuno-tolerance to the antigen throughout time. Rats were tolerized to neural antigens (t (16): 6.022, p<0.001) and this state remained at least for six months post-induction (t (15): 4.246, p<0.01). These results show that immune response can be induced and the systemic antigen specific tolerance is maintained at least until the six months postinduction. This strategy can potentially be used in any degenerative disease.
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