Journal of Nutrition & Food Sciences
Open Access
ISSN: 2155-9600
+32 25889658
ISSN: 2155-9600
+32 25889658
Morkel Jacques Otto
Harvard Medical School, United Kingdom
Scientific Tracks Abstracts: J Nutr Food Sci
Background: Disease may cause malnutrition and malnutrition may cause disease. Long-term prescribed medicine may cause malnutrition and disease. This interconnected triad complex of malnutrition, disease and prescribed medication has a negative outcome not limited to patient safety and quality of patient care, but it also results in billions of Pounds wasted and ultimately putting strain on healthcare costs and resources in the United Kingdom. The health problem that needs to be addressed is that drug-nutrient interactions causing malnutrition (nutrient deficiencies) receive very little attention from national health authorities, clinicians, pharmacists, medical school pharmacology departments, and pharmaceutical companies, despite the debilitating morbidity and mortality linked to prescribed medicine-induced malnutrition and disease, particularly in the elderly over 65 years of age. To the contrary, the focus is on side-effects and complications caused by drugs and drug-drug interactions. Vitamin D deficiency is a global pandemic dilemma and > 30% of adults are reported as having low 25(OH)D levels and an even higher prevalence in elderly patients > 65 years without compromised renal function. Vitamin D deficiency is a possible aetiological factor in several chronic debilitating conditions associated with high risk of morbidity and mortality including cardio-vascular diseases, autoimmune diseases, inflammatory bowel disease, immune deficiency, upper respiratory tract infections, malignancies, osteoporosis, type 1 and 2 diabetes mellitus, statin-intolerance and neurodegenerative disorder e.g., Alzheimer’s disease. Vitamin D deficiency is also associated with statin-intolerance. Epilepsy is the most common neurological disorder affecting approximately 50 million people worldwide. By the year 2037 it is estimated that 24% of the UK population will be over 65 years of age. However, from the age of 60 years the incidence of epilepsy increases sharply and results in increased healthcare costs not only due to prescribed anti-epileptic drugs (AEDs) but even more importantly due to AEDs-induced Vitamin D deficiency morbidity and mortality. Despite the widespread use of AEDs in the elderly there is limited information available on their kinetics in this age group and no formal practical guidelines for the management of bone disease among those taking AEDs. The main aim is either alternative AEDs prescribing or deprescribing of AEDs that are strongly related to Vitamin D deficiency by 50% over a 12-month period. The secondary aim is to prescribe Vitamin D supplementation to patients who are Vitamin D deficient and for those patients who are statin-intolerance. Methods: Proposing a pilot study using data collection instruments, electronic health records (EHRs) in one NHS Family Practice Clinic and two Community Pharmacies in a United Kingdom National Health Service Trust to identify elderly patients who are at risk from receiving long-term prescription AEDs. Anticipated challenges and barriers include assembling a multidisciplinary care team to assess and provide timely interventions, obtaining funding for costly additional screening consultations and laboratory investigations enabling early identification of patients at risk of developing osteoporosis, statin-intolerance and incident type 2 diabetes mellitus, implementing a new clinical pathway during the Covid-19 pandemic, patients with Intellectual disability, poor literacy, language barriers and patient apprehension. Strategies to overcome barriers that can make complex elderly care more manageable include the 4Ms — What Matters, Medication, Mentation, and Mobility. Sustainability depends on the study design, given the lack of a direct comparator group, and potentially finding low literacy might interfere with implementing the intervention. Results: Successful feasibility and scalability of this project depends on the following factors: (1) The importance of his project in terms of having a big enough impact in health improvement that will lead to adoption and implementation by a National Health Trust. (2) Education and motivation of clinicians and auxiliary staff is key to performing the intervention successfully and the setting up of an outreach program in creating awareness of the detrimental health effects of AEDs in the elderly. (3) Obviously, training and IT infrastructure (EMR alerts and order sets) are necessary components of an effective alert system that is mainly managed by the Superintendent Pharmacist. (4) In terms of cost, a successful project will save private patients with access to health insurance, and the National Healthcare System (NHS), money due to the reduction in unwanted morbidity. (5) As regards the system, once it's programmed, it will be easily implemented, and data can be collated, analysed and feedback provided by pharmacists. The goal is escalating this project on a United Kingdom nation-wide National Healthcare System level.
Morkel Jacques Otto is from Harvard Medical School Post Graduate Education Safety, Quality, Informatics and Leadership (SCQIL) 1-year program (2020-2021) Capstone research project.