Journal of Glycomics & Lipidomics
Open Access
ISSN: 2153-0637
ISSN: 2153-0637
Oriakhi K and Uadia P O
University of Benin, Nigeria
Posters & Accepted Abstracts: J Glycomics Lipidomics
Hyperlipidemia, a disorder of lipid metabolism characterized by elevated levels of lipids circulating in the blood, has now become a global concern. It is considered as one of the five leading cause of death in the world. A total of 35 rats were used in this study. The animals were randomly assigned into seven groups (five rats per group). Group I (control group) was fed with normal diet (ND) only, Group II, V, VI and VII were fed with high cholesterol diet, while groups III and IV were fed with normal diet for five weeks and thereafter administered with 250 and 500 mg/kg body weight of Tetracarpidium conophorum oil (TCO), respectively for a period of 20 days. Group II were maintained on hyper cholesterol diet, while Group V and VI was administered 250 and 500 mg/kg body weight of TCO, respectively for a period of 20 days, while group VII was given 80 mg/kg body weight of atorvastatin used as a reference drug. After six weeks, rats were deprived of food overnight, the animals where sacrificed. Blood sample was collected and biochemically analyzed for total cholesterol (TC), triglyceride (TG), high density lipoprotein HDL cholesterol (HDL-C), low density lipoprotein (LDL-C), malondialdehyde levels (MDA), creatine kinase(CK) and lactate dehydrogenase (LDH) activities. The results showed that there were significant increases (P<0.05) in TC, LDL-C, CK, LDH and MDA levels with a reduction in HDL-C in rats induced with high cholesterol diet after 37 days when compared to the initial values at day 0. Oral administration of Tetracarpidium conophorum oil and atorvastatin drug for a period of 20 days resulted in significant lowering (P<0.05) of the levels of TC, LDL-C, CK, LDH and MDA levels with increase in HDL-C in rats induced with high cholesterol diet. However there were also significant decreases (P<0.05) in TC, LDL-C, LDH, CK and MDA levels with increase in HDL-C in rats administered with 250 and 500 mg/kg body weight of Tetracarpidium conophorum oil alone for 20 days in rats fed with normal diet when compared to control. Tetracarpidium conophorum oil could effectively reduce or control the amount of serum cholesterol and LDL-C. It is apparent that the oil could contribute to new formulation with significant hypolipidemic effect and cardioprotective properties.
Email: kelly.oriakhi@uniben.edu