Biochemistry & Pharmacology: Open Access
Open Access
ISSN: 2167-0501
+44-77-2385-9429
ISSN: 2167-0501
+44-77-2385-9429
Olabiyi A. S, Nkemehule F. E, Odukoya O. A, Samuel T. A and Ogbonnia S. O
Accepted Abstracts: Biochem & Pharmacol
The non-enzymatic glycosylation of haemoglobin has been established and shown to be significantly increased in diabetes. Advanced glycosylation end-products (AGEs) promote the development and progression of diabetic complications. Twenty plants were selected from Lagos metropolis in Nigeria for the study. The inhibitory properties of the ethanolic extracts of each plant on glycosylation of haemoglobin as an index of antidiabetic property were investigated using quercetin as Standard. The ethanolic (96%) extracts of the plants were phytochemically analyzed for the presence of phenolic compounds and the total phenolic content of the plants was measured by Folin-Ciocalteu's reagent using gallic acid as a standard. Lophira alata was found to contain the highest amount of phenols with a concentration of 0.515 mg/ml and Citrullus lanatus had the lowest concentration of 0.007 mg/ml. Five plants showed a higher percentage inhibition of glycosylation than quercetin which showed a percentage inhibition of 10.155%. They are Alstonia congensis, Vernonia amygdalina, Alstonia boonei, Sarcocephalus latifolius, Azadirachta indica and Gongronema latifolium with percentage inhibition of 24.799%, 20.310%, 16.429%, 14.036%, 13.441% and 11.953% respectively. From the study, fifteen out of the twenty plants analyzed inhibited the binding of glucose to haemoglobin and thus may be used as adjuncts in antidiabetic therapy.