Journal of Developing Drugs
Open Access
ISSN: 2329-6631
+44 1478 350008
ISSN: 2329-6631
+44 1478 350008
Partha Sarathi Guin
Shibpur Dinobundhoo Institution, India
Posters & Accepted Abstracts: J Develop Drugs
Anthracycline drugs are chemotherapeutic agents that are in use for the treatment of various human cancers. However, this category of drugs is so expensive that most patients belonging to the developing countries cannot afford to practice these drugs. Therefore, efforts are presently afoot to evaluate new but comparatively less expensive substitutes of the known forms of these drugs which is why in the present study we chose 1-amino-4-hydroxy-9, 10-anthraquinone (QH) and its copper complex (CuQ2). The electronic and molecular structures of the molecules were analyzed by theoretical studies such as DFT, NBO, VEDA, TDDFT, etc., and corroborated with the experimental findings. Various physicochemical and biochemical aspects of these molecules such as electrochemical behavior, enzymatic studies, DNA interaction and aspects of hydrophobic and hydrophilic interaction with micelles as model for biomembrane were studied by using different techniques as these are important for the drug action for this class of molecules. Finally the compounds were applied to human breast adinocarcinoma cell MDA-MB-231 in order to check their biological efficacy. It was found that the molecules induce apoptosis in this adinocarcinoma cell, with little, if any; cytotoxic effect in HBL-100 normal breast epithelial cell and CuQ2 brings a better apoptoic action in comparison to QH. The electrochemical aspects, structural characteristics and the affinity of the molecules to interact with DNA and micelles possibly play a role behind their action as a potent antitumor agent and this may raise the hope that these molecules may be used as antitumor drugs in near future.
Email: parthasg@gmail.com