Journal of Clinical & Experimental Dermatology Research
Open Access
ISSN: 2155-9554
+44 1478 350008
ISSN: 2155-9554
+44 1478 350008
Dong Ming-Li
Accepted Abstracts: J Clin Exp Dermatol Res
Lethal midline granuloma (LMG) describes an entity of clinical-pathologic syndrome characterized by progressive swelling, ulceration, and destruction of the central face that is usually fatal. Pathological features are inflammation, necrosis, and granulation, none of which is specific. The disorder was renamed as various names, and in recent years, with NK/T cell lymphoma. However, diagnosis still relies on the progressive necrosis course rather than malignancy in histology. The disease has long challenged physicians, particularly when it worsened with radiotherapy or chemotherapy but sometimes achieved total remission without anti-malignancy therapies. We describe a 35-year-old man who had typical clinical-pathological symptoms of LMG, and also the symptoms of Rhizomucor variabilis infection. Diagnosis and management was really on the crossroads of the two diseases that would lead to different result. Epidemiology, clinical manifestations, radiographic characteristics, and pathologic features of LMG and R variabilis infection were discussed.