Endocrinology & Metabolic Syndrome
Open Access

Letrozole versus combined metformin and clomiphene citrate for ovulation induction in clomipheneresistant women with polycystic ovary syndrome: A randomized controlled trial

Polycystic Ovarian Syndrome Conference

November 16-18, 2015 Seattle, USA

Hatem Abu Hashim

Mansoura University, Egypt

Posters-Accepted Abstracts: Endocrinol Metab Syndr

Abstract :

Objective: To compare the effect of letrozole with combined metformin and clomiphene citrate (CC) for ovulation induction in CCresistant women with polycystic ovary syndrome (PCOS). Method & Design: A randomized controlled trial. Setting: University teaching hospital and a private practice setting. Patients: Two hundred fifty anovulatory women (582 cycles) with CC-resistant PCOS. Interventions: Patients received 2.5 mg of letrozole daily (123 patients, 285 cycles) or combined metforminâ��CC (127 patients, 297 cycles) for three treatment cycles. Main Outcome Measures: Ovulation rate, number of follicles, serum E2, serum P, endometrial thickness, pregnancy and miscarriage rates. Results: Ovulation occurred in 185/285 cycles (64.9%) in the letrozole group versus 207/297 cycles (69.6%) in the combined metformin-CC group, without statistically significant difference. The total number of follicles was significantly more in the combined metformin-CC group (4.4�±0.4 vs. 6.8�±0.3). A non-significant increase in endometrial thickness on the day of hCG administration was observed in the letrozole group (9.5�±0.2 mm vs. 9.1�±0.1 mm). No statistically significant difference regarding the pregnancy rate (PR) was observed between both groups (14.7% vs. 14.4%). Conclusions: Letrozole and combined metformin-CC are equally effective for inducing ovulation and achieving pregnancy in patients with CC-resistant PCOS.

Biography :

Email: hatem_ah@hotmail.com