Journal of Developing Drugs
Open Access

Long-term effect of mass Chemotherapy of Schistosoma mansoni on infection rate and Diagnosis accuracy

Joint International Conference and Expo on Industrial Pharmacy & 5th Global Pharmacovigilance Summit

April 28-29, 2016 Dubai, UAE

Yasser Elsherif

National Liver Institute, Egypt

Posters & Accepted Abstracts: J Develop Drugs

Abstract :

Mass treatment has been adopted by many countries with high prevalence of schistosomaisis infection. Evidence suggests that it has significantly reduced the prevalence of the infection. More recently, however, questions aroused about its long term benefits. The main diagnostic method used to assess infection rates was based on microscopic stool examination that has several weaknesses in the process of schistosomiasis diagnosis. We performed this study to assess the performance of microscopic examination that is widely used for the diagnosis and assessment of infection rates of S. mansoni in Egypt for the evaluation of chemotherapy and control measures efficacy after a decade of regular mass treatment. A total of 651 (55 children and 596 adults) individuals from three endemic governorates in Lower Egypt, were examined for ova by microscopic stool examination (MSE) alone, rectal biopsy (RB) alone or both MSE+RB. Although all patients came from same background, infection detection rates substantially changed according to method of diagnosis. It was significantly low in MSE alone group (9%) compared to RB alone group (40.6%) and to RB+MSE (37.7%) group. In MSE+RB group, MSE failed to diagnose 86.5% (148/171) of positive cases detected by rectal biopsy. The sensitivity of MSE was significantly lower than RB, 13.5% vs. 98.8%. We found that true prevalence in endemic communities (e.g. Egypt) may be considerably underestimated. The use of simple microscopic examination for monitoring infection is ineffective because of low sensitivity.

Biography :

Email: yassherif@hotmail.com