Journal of Clinical and Experimental Ophthalmology
Open Access
ISSN: 2155-9570
ISSN: 2155-9570
Jufang Huang, Lihong Zhou, Tu Hu, Shuchao Wang and Dan Chen
Central South University, China
Scientific Tracks Abstracts: J Clin Exp Ophthalmol
Many researches on retinal injury and repair following High Intraocular Pressure (HIOP) suggested that the survival ratio of Retinal Ganglion Cells (RGCs) have been improved much by kinds of measures. However, the visual function recovery is far lower than expected. Previous studies found that the homeostasis of the synapse in visual signal pathway is the key structural basis for the delivering of visual signals in vivo. While, the studies from our group indicated that the complicated synaptic plasticity of retinal neurons occurred much earlier than obvious degeneration of RGCs in rat retinae. We speculate that the retinal synaptic plasticity may be one a key reason for the limited visual function recovery under kinds of RGCs repair means following HIOP. Exploring the modulatory mechanisms of synaptic plasticity after HIOP may provide new ideas for better visual function recovery. Interestingly, macroglia was found activated after HIOP and inhibiting its activation could suppress the alteration of synapse following acute HIOP. Thus, retinal macroglia may participate in the modulation of synaptic plasticity in rat retina after HIOP. From in vivo and in vitro study, we proved that macroglia modulated retinal synaptic plasticity through delivering Trombospondin 2 (TSP2), which bounds to its neuronal receptor �±2�´1 to promote synaptogenesis. These results may provide new evidences to retinal repair strategies for better visual function recovery on intervention time points and targets after HIOP.
Jufang Huang is currently working as a Professor in Department of Anatomy and Neurobiology at Xiangya School of Medicine, Central South University located in Changsha Hunan Province, China.
Email: huangjufang@csu.edu.cn