Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
+44 1223 790975
ISSN: 0974-276X
+44 1223 790975
Carles Celma Lezcano
Kymos Pharma Services, Spain
Scientific Tracks Abstracts: J Proteomics Bioinform
The lecture will be mainly focalised in the structural characterization of recombinant proteins following the recommendations of the ICH Q6B. Although several aspects of the protein characterization will also be pointed, the discussion will be focalized in the study of the primary structure of the protein by mass spectrometric methods. The quality attributes treated will be: ΓΆΒ?ΒΆ Peptide mapping ΓΆΒ?ΒΆ Amino acid sequence confirmation ΓΆΒ?ΒΆ Mass determination of the whole molecule ΓΆΒ?ΒΆ N and C terminus verification ΓΆΒ?ΒΆ Posttranslational modifications A discussion on the technical approaches for these quality attributes will be presented and examples will be provided.
Carles Celma Lezcano did his PhD in Organic Chemistry, specifically in peptide synthesis and MS characterization. As a professional, he has more than 20 years of experience in mass spectrometry and developed his career at IPSEN Pharma as Bioanalysis Director and currently holds the position of Director of biologics at Kymos Pharma.
Email: ccelma@kymos.es