Journal of Clinical Toxicology
Open Access

Medical implications of reduction of blood lead levels in children after polluted site remediation in Meza valley, Slovenia

4^th Global Summit on Toxicology

August 24-26, 2015 Philadelphia, USA

Zala Lestan

Posters-Accepted Abstracts: J Clin Toxicol

Abstract :

The Meza valley, Slovenia has long been contaminated by lead smelting, resulting in widespread lead poisoning in childhood. Due
to behavioral and physiologic charactaristics, young children are most at risk of exposure and long-term negative effects of lead
poisoning. Blood lead levels below the action threshold of 10 μg/dl (Slovenian legislation) or even 5 μg/dl (CDC recommended) are
proven to be in correlation with a reduction of IQ, behavioral and academic problems, hormonal imbalances, growth retardation,
arterial hypertension and cumulative cardiovascular risk as well as nephrotoxicity in vulnurable individuals. As these consequences
of lead exposure are usually permanent and long-term detrimental effects are present even after an isolated exposure event due to
the accumulation of lead in the body, the only feasible way of preventing lead-associated morbidity is to reduce environmental lead
values. The potential of mitigating the risk of lead poisoning by remediation of soil with EDTA has been investigated by applying the
Integrated Exposure Uptake Bio-Kinetic (IUBK) model. The IUBK model predicted that soil remediation would successfully decrease
the number of locations at which the predicted blood lead level exceeds the stipulated of 10 μg/dl by 90, 38 and 91% respectively, in
the towns of Mezica, Crna and Zerjav. The mean blood lead level in 3-year old children was predicted to decrease by approximately
a half. This reduction is particularly important in the case of Zerjav, where in some areas the values of BLL reach levels over 30 μg/dl
that can be associated with clinically overt lead poisoning.

Biography :

Zala Lestan has graduated from the Medical Faculty of the University of Ljubljana in 2014. She has obtained her Medical License in 2015. She is currently involved in
research at the Department of Pulmonary Disease and Allergy of the University Medical Center Ljubljana.