Virology & Mycology
Open Access
ISSN: 2161-0517
ISSN: 2161-0517
Khalid Abdallah Mohammed Enan
The Ministry of Higher Education and Scientific Research, Sudan
Posters & Accepted Abstracts: Virol-mycol
Human cytomegalovirus (HCMV) infection still represents the most common with potentially serious viral complication in humans and is a major cause of congenital anomalies� in infants. This study was aimed to detect HCMV in infants with congenital anomalies. Study subjects consisted of infants born with neural tube defect, hydrocephalus (HC) and microcephaly. Fifty serum specimens (20 males, 30 females) were collected from different hospitals in Khartoum state. The sera were investigated for Cytomegalovirus specific immunoglobin M (IgM) antibodies using enzyme-linked immunosorbent assay (ELISA) and for Cytomegalovirus DNA using polymerase chain reaction (PCR). Out of the 50 sera tested, one patient�s (2%) sample showed HCMV IgM but with no detectable DNA by using PCR, another 4 (8.2%) sera were positive for HCMV DNA by using PCR but with no detectable IgM using ELISA. Various diagnostic techniques should be considered to evaluate HCMV disease and routine screening for HCMV should be introduced for pregnant women in this setting. It is vital to initiate further research work with many samples from different area to assess prevalence and characterize HCMV and evaluate its maternal health implications.
Email: khalid.enan@gmail.com