Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
ISSN: 0974-276X
Himansu Sekhar Nanda Lelin Patel, Poonam Suthar, Nidhi Gaur, Rajanikantha Nahak
Scientific Tracks Abstracts: J Proteomics Bioinform
The nucleocapsid protein N plays a common functional role in different RNA viruses by enwrapping the viral genomic RNA in an RNase-resistant form. The homology model of the protein was generated using Modeller software based one avaiable structural homologues in protein databases. The final model obtained by molecular mechanics and dynamics method was validated by PROCHECK and DOPE scores, which showed that the refined model is reliable. Functional assignment of the protein by SVM program has been elucidated. The model could prove useful for further inhibition of the protein to design novel antiviral drug candidates. Ligand protein inrteraction study of the modeled protein N and different antiviral drug candidates showed that few drugs like acyclovir, vidarabine and ribavirin can be implicated for Chandipura virus disease as these drugs have have shown very high similarity in docking scores of the target, template and other reported proteins of different viruses.