Journal of Antivirals & Antiretrovirals
Open Access

Multifunctional magnetic nanocarrier for drug targeting to brain

International Conference and Exhibition on VIROLOGY

5-7 September 2011 Baltimore, USA

Madhavan P.N Nair

Scientific Tracks Abstracts: JAA

Abstract :

Opiates act synergistically with HIV-1 proteins to potentiate the HIV-related neurotoxicity that leads to development of NeuroAIDS. Currently no eff ective treatment exists for NeuroAIDS, which is mainly attributed to the impenetrability of therapeutic molecules across the blood-brain barrier (BBB). We herein report development of a magnetic nanocarrier of AZT 5�-triphosphate (active form of Azidothymidine) and CTOP (a potent �¼-opioid receptor antagonist) for delivery across the BBB under the infl uence of an external magnetic fi eld. Th e proposed nanocarrier is anticipated to simultaneously reduce NeuroAIDS and opiate addiction in HIV-1 infected subjects who are opiate users.