Journal of Glycobiology
Open Access

Neuraminidase-1 and its role in multistage tumorigenesis

4^th Glycobiology World Congress

September 17-19, 2018 | Rome, Italy

Myron R Szewczuk

Queens University, Canada

Keynote: J Glycobiol

Abstract :

Neuraminidase-1 (Neu1) has recently emerged as a central target in sialidase-mediated regulation of tumorigenesis. Recent evidence indicates that Neu1 plays a much more profound role in human cancers than previously expected. It is essential in the clinical setting that targeted therapies are to circumvent multistage tumorigenesis, including genetic mutations at the different growth factor receptors, tumor neovascularization, chemoresistance, immune-mediated tumorigenesis and the development of tissue invasion and metastasis. Firstly, the cell-surface molecular signaling platform will be described in controlling Neu1 sialidase activity, and discuss its relevance in cancer cell signaling. Second, the current understanding of Neu1 activity associated with cancer development will be summarized, and outline the key roles of Neu1 during various stages of tumorigenesis, including regulation of growth factor receptor signaling, control of TOLL-like receptor (TLR) signaling and immune-mediated tumorigenesis, regulation of epithelialmesenchymal transition (EMT), metastasis and acquired chemoresistance, and regulation of tumor vascularization.

Biography :

Myron R Szewczuk for the past 35 years, Dr. Szewczuk is Full Professor of Immunology and Medicine, Queen’s University, Kingston, Ontario Canada. Dr. Szewczuk’s recent research has focused on the role of glycosylation in receptor activation with a particular focus of TOLL-like, nerve growth factor Trk, EGFR and insulin receptors. He has discovered a novel receptor-signaling platform and its targeted translation in multistage tumorigenesis.

E-mail: szewczuk@queensu.ca