Journal of Cell Science & Therapy
Open Access
ISSN: 2157-7013
+44 1300 500008
ISSN: 2157-7013
+44 1300 500008
Wael Abo El-Kheir
Egyptian Society for Progenitor Stem Cell Research, Egypt
Posters & Accepted Abstracts: J Cell Sci Ther
Background: Stem cell-based therapies provide hope for various CNS diseases including perinatal hypoxic ischemic insults of the brain. Stem cells have the capacity to proliferate in culture, migrate and disseminate following implantation within the adult CNS. The neuroregenerative potential of bone marrow derived mesenchymal stem cells (MSCs) is proposed to be through paracrine effect, stimulation of endogenous stem cells, angiogenesis, in addition to the disputed possibility of direct trans-differentiation. Objectives: To study the impact of MSC transplantation on psychomotor functions in patients with cerebral palsy. Methods: Fifty two Egyptian patients with cerebral palsy were divided into: Group I (26 patients who underwent autologous intrathecal bone marrow-derived mesenchymal stem cell injection) and Group II (26 patients who served as control). Both groups were assessed, initially and after one year, by a group of clinical scales to assess motor, communication and independence skills. Results: In Group I, using Boyd�s developmental progress scale revealed a statistically highly significant improvement in motor, independence and communication skills after SCT (P value<0.01). Also, 100 points scale revealed a statistically significant improvement after SCT (P value<0.05). Conclusion: Autologous stem cell transplantation could be a useful tool for the management of patients with cerebral palsy as it may help in improvement of motor, independence and communication skills.
Email: dr.wael2008@yahoo.com