Journal of Cancer Science and Research
Open Access

NEW APPROACH TO CANCER THERAPY: HIF2a INHIBITORS

International Conference on Cancer Science and Research

July 13-14, 2021 WEBINAR

Karolina Kozal

Institute of Biochemistry, Department of Cytobiochemistry, University of Lodz, Poland

Scientific Tracks Abstracts: J Can Sci Res

Abstract :

Hypoxia is a common feature associated with many types of cancer. Insufficient oxygenation state intensifies genome instability, promotes progression, enables avoidance of the immune response, and takes part in developing more aggressive phenotypes resistant to chemotherapy, radiotherapy, and photodynamic therapy. The activity of the hypoxiainducible factor, the critical element of response and adaptation to hypoxia, enhances cancer hallmarks such as suppression of the immune response, altered metabolism, angiogenesis, invasion and metastasis, and more. Although the HIF transcriptional factor is an intensively researched target of antitumor therapy, currently used agents target it indirectly (through topoisomerase I, mTOR, HSP90, etc.). The new inhibitors, PT2385, and PT2977 are first-in-class compounds targeting HIF directly. Moreover, they target isoform HIF2�?, which is believed to maintain chronic hypoxia that characterizes advanced tumors. This poster briefly summarizes basic knowledge about hypoxia in cancers and activity of the hypoxia-inducible factor, shows structures of the new agents and discrepancies between their activity and previously used inhibitors. The poster also includes the preliminary results of PT2385 clinical trials and the schedule of the next planned clinical trials. This poster aims to signal the appearance of the new approach in the field of inhibiting the hypoxia-inducible factor.
Recent Publications:
Kozal K. Role of the hypoxia-inducible factor in the metabolism of cancers and its inhibitors in anticancer therapy., Nauka, Badania i Doniesienia Naukowe 2020: Nauki przyrodnicze i medyczne / Wysocza�?ski Tobiasz ( eds. ), vol. 1, 2020, Idea Knowledge Future, ISBN 978-83-953882-6-2, pp. 79-87
Jóźwiak, P., Ciesielski, P., Forma, E., Kozal, K., Wójcik-Krowiranda, K., Cwonda, Ł., Bie�?kiewicz, A., Bry�?, M., & Krze�?lak, A. (2020).
Expression of voltage-dependent anion channels in endometrial cancer and its potential prognostic significance. Tumor Biology. https://doi.org/10.1177/1010428320951057
Jóźwiak P, Ciesielski P, Zakrzewski PK, Kozal K, Oracz J, Budryn G, Żyżelewicz D, Flament S, Vercoutter-Edouart A-S, Bray F, Lefebvre T, Krze�?lak A.
Mitochondrial O-GlcNAc Transferase Interacts with and Modifies Many Proteins and Its Up-Regulation Affects Mitochondrial Function and Cellular Energy Homeostasis. Cancers. 2021; 13(12):2956. https://doi. org/10.3390/cancers13122956