Journal of Clinical and Experimental Ophthalmology
Open Access

New insights in the pathogenesis and treatment of glaucoma

2^nd International Conference on Eye and Vision

September 26-28, 2016 Orlando, USA

Maneli Mozaffarieh

Augenglatt Zentrum Z�¼rich, Switzerland

Posters & Accepted Abstracts: J Clin Exp Ophthalmol

Abstract :

Increased intraocular pressure (IOP) is a major risk factor for glaucomatous damage and reducing IOP improves prognosis. Nevertheless, there is little doubt that other risk factors besides IOP such as unstable ocular perfusion are involved. Blood flow is unstable, if either the IOP fluctuates at a high level (or blood pressure fluctuates at a low level) or if the autoregulation of blood flow is disturbed. A common cause for a disturbed OBF autoregulation is a primary vascular dysregulation (PVD) in context of the Flammer-syndrome. An unstable blood flow leads to recurrent mild reperfusion injury (chronic oxidative stress) affecting particularly the mitochondria of the optic nerve head. OBF regulation can be improved by magnesium, calcium channel blockers as well as with carbonic anhydrase inhibitors. Oxidative stress can be reduced at the mitochondrial level by ginkgo biloba.

Biography :

Email: maneli.mozaffarieh@gmail.com