Journal of Physical Chemistry & Biophysics
Open Access
ISSN: 2161-0398
+44 1478 350008
ISSN: 2161-0398
+44 1478 350008
E Drakaki1, I Stefana2, C Dessinioti2, I A Sianoudis3, M Makropoulou1A, A Serafetinides1, E Christofidou2, A J Stratigos2, A D Katsambas2 and Ch. Antoniou2
1National Technical University of Athens, Greece 2University of Athens, Greece 3Technological Educational Institute of Athens, Greece
Posters-Accepted Abstracts: J Phys Chem Biophys
Photodynamic therapy is a non-invasive therapy for non-melanoma skin cancer. Photodynamic therapy involves the activation of a photosensitizing drug by visible light to produce activated oxygen species within target cells, resulting in their destruction. In addition to its therapeutic uses, optical spectroscopy is a helpful tool to prove the efficacy of PDT. It provides information on the distribution and degradation of sensitizers at the tumor�s treatment area, the formation of fluorescent photoproducts, changes in tissue auto fluorescence, light absorption and scattering in tissue induced by photodynamic treatment. In this project photodynamic therapy (PDT) with topical application of methyl 5-aminolevulinate was used to treat non-melanoma skin cancer and actinic keratosis. The interval between the photosensitizer application and illumination was 3 hours. The incident light dose was mostly 75 J cm�2, at ~635 nm wavelength. An imaging system was used to monitor spectroscopic signals during the PDT of tumors to display the localization and extension of skin tumors and to check therapy effectiveness.The spectra were classified and compared to histopathology to evaluate the efficiency in diagnostic discrimination employing optical spectroscopic techniques. Our findings indicate the potential of combination of PDT and spectroscopy as a reporter of treatment outcome. Further work is under way, in order to establish optimal treatment schemes.
Email: edrakaki@gmail.com