Journal of Pharmaceutical Care & Health Systems
Open Access
ISSN: 2376-0419
+44 1300 500008
ISSN: 2376-0419
+44 1300 500008
Khalid T Alharbi, Mohamed A Albekery, Saqer Alarifi, Dilshad Ahmad, Mustafa A Mustafa and Alaa Eldeen Yassin
King Saud bin Abdulaziz University for Health Sciences, KSA
Posters & Accepted Abstracts: J Pharma Care Health Sys
Purpose: To optimize a Nanostructured Lipid Carriers System (NLCS) for the per-oral delivery of Valsartan (Val), a model BCS class II drug, in an attempt to enhance its therapeutic performance by increasing both solubility and dissolution. Methods: Val-loaded NLCs were prepared using ultrasonic melt-emulsification method. Number of formulation factors including the type of oil/lipid, Val to lipid ratio, and surfactant ratio were investigated. The prepared NLC were evaluated for their particle size, polydispersity index, zeta potential, and drug entrapment efficiency. The in vitro drug release profiles were evaluated using a dialysis bags with cut-off 12 KD. Results: The prepared NLCs showed average sizes between 423.99�±12.73 and 805.53�±178.5nm, and polydispersity index in the range of 0.272 to 0.349. The zeta potential values were between -3.34 and -10.59mV. The entrapment efficiency was not very high between 43.5 to 63.7%. The in vitro release followed a bi-phasic pattern with an initial rapid Val release followed by a slow release varying according to the composition. Two formulations F2 and F4 showed complete drug release within the first two hours. The optimum surfactant ratio was 25% by weight of the total lipid. The 1 to 9 drug to lipid ratio was the optimum for the particle size and EE. Conclusion: NLC successfully enhanced the Val release rate and dissolution with high potential to enhance its bioavailability.
Khalid Al Harbi is currently doing Internship at National Guard Hospital-Riyadh, Saudi Arabia. He has recently completed his PhD from King Saud bin Abdul-Aziz University for Health Sciences, KSA. He has published 3 papers in reputed journals.
Email: ph.khalid3@gmail.com