Journal of Clinical & Experimental Dermatology Research
Open Access

Organic silicium increases the synthesis of hyaluronan synthase 2 gene transcript coding for the enzyme responsible for native hyaluronic acid production

7^th European Dermatology Congress

June 13-14, 2016 Alicante, Spain

Evgeniya Ranneva, Pierre-Antoine Deglesne, Rodrigo Arroy O and Philippe Deprez

Skin Tech Pharma Group, Spain

Posters & Accepted Abstracts: Clin Exp Dermatol Res

Abstract :

Organic silicium has been used for decades in mesotherapy procedures; although its beneficial properties for the skin have been widely observed, poor scientific documentations describing the molecular mechanisms involved can be found. An in vitro assay has been performed on medical device CE Class III that contains organic silicium associated to resveratrol and viniferins for efficacy assessment on human fibroblast. Cell proliferation following the exposure to the actives in particular conditions has been evaluated. Medical device Class CE III based in organic silicium is able to increase hyaluran synthase 2 gene expression 26 times (corresponding to a 2400% increase). HAS2 in human is responsible of the majority of High Molecular Weight Hyaluronic Acid synthesis. Among the three HAS proteins present in human, HAS2 is the only one essential for life. Hyaluronan synthase 2 protects skin fibroblasts against apoptosis induced by environmental stress. Organic silicium capability to renew extracellular hyaluronic acid content is suggested by its capacity to induce high levels of HAS2 in vitro.

Biography :

Email: drranneva@clinicahera.es