Clinical & Experimental Cardiology
Open Access

Oxidative stress-induced effects on proinflammatory cytokines and vascular endothelial growth factor after interventional treatment of coronary heart disease

18^th Annual Cardiologists Conference

June 19-21, 2017 Paris, France

Khaybullina Zarina Ruslanovna, Zarina Khaybullina, Mirjamol Zufarov, Nodir Sharapov, Saidarifkhon Murtazaev and Saodat Abdullaeva

Republican Specialized Center of Surgery, Uzbekistan

Posters & Accepted Abstracts: J Clin Exp Cardiolog

Abstract :

This study aimed to investigate vascular endothelial growth factor (VEGF), reactive oxygen species (ROS) and proinflammatory cytokines: interleykin-6 (IL-6), tumor necrosis factor alpha (TNF-a), C-reactive protein (CRP) in the blood of the patients with coronary heart disease (CHD) after percutaneous coronary intervention (stenting) and coronary bypass operations (CBO). Malondialdehyde (MDA), IL-6, TNF-a, CRP, VEGF was analyzed in 95 patients with CHD preand post-procedure. CRP was made in automatic biochemical analyzer â�?�?VITROS-350â�? (USA). IL-6, TNF-alpha, VEGF was measured using ELISA kits. All of investigated markers increased versus the control before treatment (p<0.05). MDA and CRP levels didnâ�?�?t change early after coronary stenting, but increased on 49% and 50.8% respectively after coronary bypass operations. TNF-alpha was increased both after stenting and coronary bypass on 39% and 110% respectively versus pre-procedural level. Correlation link MDA/TNF-a have coverage force (r=0.53, p<0.05) after CBO, whereas after coronary stenting it was weak (r=0.11, p>0.05). IL-6 and VEGF concentration decreases after stenting (on 1, 5 and 2, 2 times versus pre-procedural) and significantly increases at 30th day after CBO (1, 3 and 10, 1 times versus pre-procedural, p<0.05). This data suggest that coronary revascularization by stenting does not accompanied by ROS overproduction and inflammation; neointimal proliferation and intracellular matrix remodeling decreases after stenting. Coronary bypass operations leads reinforcement of inflammatory response and ROS generation, that causes prolonged oxidative stress. In this condition, neo angiogenesis activation approved by VEGF may be broken. Inflammation and oxidative stress after coronary bypass operations can have influence on outcomes of treatment.

Biography :

Email: zrkhaybullina1@gmail.com