Journal of Clinical & Experimental Dermatology Research
Open Access

Palisaded encapsulated neuroma: An unusual presentation

Joint Conference on 9^th Clinical Dermatology Congress & 2^nd International Conference on Psoriasis, Psoriatic arthritis & Skin infections

October 16-18, 2017 New York, USA

Jaskaran Batra

Safdarjung Hospital, India

Posters & Accepted Abstracts: J Clin Exp Dermatol Res

Abstract :

Palisaded encapsulated neuroma (PEN) is a distinctive benign neural tumor, which usually presents as small, solitary, asymptomatic, firm, rubbery, skin-colored or pink papule or nodule, almost always present on the face or close to a mucocutaneous junction. It commonly occurs in middle-aged adults with female to male ratio of 1:1. Rarely, it can present with multiple lesions. Even though it is not uncommon, it has received minimal attention and is very poorly known among pathologists. Clinically, PEN is most commonly confused with neurofibroma, basal cell carcinoma, nevus, or skin appendage tumor. PEN has histological appearance between that of a neurofibroma and a schwannoma situated predominantly in the dermis. Differentiation from neurofibromas is essential, because the latter is often associated with neurofibromatosis, and has a propensity for malignant transformation. PEN has no association with neurofibromatosis or multiple endocrine neoplasia syndrome type 2B (MEN 2B). Even after incomplete excision PEN does not recur, a fact supporting a reactive rather than a neoplastic origin. Here, we present a rare case of multiple cutaneous PEN in a dermatomal distribution on the face not associated with neurofibromatosis or MEN 2B.