Reproductive System & Sexual Disorders: Current Research
Open Access
ISSN: 2161-038X
+44 1300 500008
ISSN: 2161-038X
+44 1300 500008
Kayode Omowumi Titilola
Landmark University, Nigeria
Posters & Accepted Abstracts: Reprod Syst Sex Disord
This study investigated the effects of the aqueous extract of P. nigrescens leaves in amelioration of spermatogenic, testicular and prostatic function alterations induced in Wistar rats via administration of paroxetine hydrochloride. Reproductive dysfunction was achieved by oral administration of 10 mg/kg paroxetine suspension to the rats for 21 days; the extract (20, 40 and 80 mg/kg body weight) and the reference herbal drug, PowmaxM (7.14 mg/kg body weight) were subsequently administered once daily for seven days and their effects were determined on functional indices of the sperm, testes and prostate. Standard methods were used for the determination of sperm motility, morphology, prostatic citrate, phosphate, calcium and pH, as well as testicular sialic acid, total cholesterol, glycogen, lactate dehydrogenase (LDH), acid phosphatase (ACP), alkaline phosphatase (ALP) and gamma glutamyl transaminase (GGT). Administration of paroxetine resulted in decreased concentration (p<0.05) of citric acid, calcium, phosphate, sialic acid, cholesterol, glycogen, protein, sperm count, sperm motility, progressive assessment and morphology. ACP, ALP, LDH, GGT, colour and pH of the semen did not reveal any significant change (p<0.05). There was significant recovery for all the group�s sequel to administration of the extracts and PowmaxM, except for alkaline phosphatase and lactate dehydrogenase that were significantly reduced (p<0.05) and gamma glutamyl transaminase and acid phosphatase that were significantly increased (p<0.05) compared to control values. The most significant results were however recorded for the 40 and 80 mg/kg extract groups. The extract positively modulates spermatogenic, testicular and prostatic functions in paroxetine induced reproductive tissue dysfunction.