Clinical & Experimental Cardiology
Open Access
ISSN: 2155-9880
+44 1300 500008
ISSN: 2155-9880
+44 1300 500008
Ishaq Khan
Mediks International Hospital/ Research Centers, Pakistan
Scientific Tracks Abstracts: J Clin Exp Cardiolog
Diabetic cardiomyopathy is the manifestation of myocardial dysfunction in the absence of coronary artery disease and hypertension. Hyperglycemia seems to be central to the pathogenesis of diabetic cardiomyopathy and to trigger a series of maladaptive stimuli that result in myocardial fibrosis and collagen deposition. These processes are thought to be responsible for altered myocardial relaxation characteristics and manifest as diastolic dysfunction on imaging. Innovative imaging technologies also have indorsed the detection of elusive systolic dysfunction in the diabetic myocardium. In the early stages, these changes appear reversible with tight metabolic control, but as the cardiac lesion become organized, the changes are irreversible and contribute to an excess risk of heart failure among diabetic patients independently of common comorbidities, such as coronary artery disease and hypertension. Therapeutic agents specifically targeting processes that lead to these pathophysiologic changes are in the early stages of development. Although glycemic control and early administration of neuro hormonal antagonists remain the cornerstones of therapeutic approaches, newer treatment modalities are currently being explored.
Ishaq Khan has completed his PhD at the age of 55 years from Walden University is also Research Affiliate. He is working as research scholar Mediks International Hospital & Research Centers. He has Published 3 books and 350 papers on medical and social sciences in reputed Journals. He is also working as editor Journal of Medicine & Health Sciences.