Endocrinology & Metabolic Syndrome
Open Access
ISSN: 2161-1017
+44 1478 350008
ISSN: 2161-1017
+44 1478 350008
Soraya Hosseini
Cornell University, USA
Posters & Accepted Abstracts: Endocrinol Metab Syndr
Electro-analytical methods have been broadly employed in monitoring a range of parameters in biomedical science. We have developed a novel approach for the fabrication of a non-enzymatic biosensor based on silver oxide/Nanodiamond/CNT to detect glucose by introducing sago as a natural hydrogel as the composite cross-linker in order to enhance the physical stability of the electrode (Ag2O/ND/CNT/Sago). A well-defined redox peak with a formal potential value of ΓΆΒ?Β?0.68 V was observed in a phosphate buffer carrier (0.01 M, pH 6.8). The redox potentials shifted slightly with a change in concentration and scan rate, indicating an irreversible reaction without observing an oxidation peak. A change in glucose concentration caused the reduction peak to move towards more negative potentials with a maximum peak at around ΓΆΒ?Β?1.1 V, suggesting the conversion of H2O2 to water. The performance and management of the two types of non-enzymatic glucose biosensors i.e. Ag2O/ND/CNT and Ag2O/ND/CNT/Sago were also evaluated in diabetes application. By adding sago as the crosslinking agent, the CV curves exhibited lower performance with a higher stability in comparison to Ag2O/ND/CNT since the activity of Ag2O/ND/CNT/Sago is deeply buried in a protective shell of the biopolymer making it difficult for direct electron transfer. The fabricated electrode demonstrated a fast detection response to glucose non-enzymatically in a concentration range from 1 to 100 mM with a good sensitivity. However, a negligible rise in current with the modified electrode (i.e. Ag2O/ND/CNT/Sago) was observed due to the absence of the catalytic activity of the electrode toward glucose reduction.
Email: soraya20h@gmail.com