Journal of Chromatography & Separation Techniques
Open Access

Polyoxygenated cembrane diterpenoids from the soft coral Sarcophyton ehrenbergi

International Summit on Current Trends in Mass Spectrometry

July 13-15, 2015 New Orleans, USA

Chang-Yih Duh

Posters-Accepted Abstracts: J Chromatogr Sep Tech

Abstract :

Five new polyoxygenated cembranoids, named (+)-1,15-epoxy-2-methoxy-12-methoxycarbonyl-11E-sarcophytoxide (1), (+)-2-epi-12-methoxycarbonyl-11E-sarcophine (2), 3,4-epoxyehrenberoxide A (3), ehrenbergolD (4) and ehrenbergol E (5), were obtained from the soft coral Sarcophyton ehrenbergi. The structures of 1-5 were established on the basis of comprehensive HRMS and NMR analyses and by comparison with reported data in literature. Compounds 4 and 5 showed moderate cytotoxicity against P-388 (mouse lymphocytic leukemia) cancer cell line with EC50 values of 2.0 and 3.0 μM, respectively. Compound 2 exhibited slight antiviral activity against HCMV (human cytomegalovirus) with IC50values of 25.0 μg/mL.