Pancreatic Disorders & Therapy
Open Access
ISSN: 2165-7092
+44 1478 350008
ISSN: 2165-7092
+44 1478 350008
Ugochukwu Offor, Naidu ECSa and Azu OO
University of KwaZulu-Natal, South Africa
Scientific Tracks Abstracts: Pancreat Disord Ther
Diabetic nephropathy (DN) has become a primary cause of end-stage kidney disease. Several complex dynamics converge together to accelerate the advancement of DN. The study was carried out to explore the mechanism of reno-protective nature of Momordica Charantia (MC) in streptozotocin (STZ) - induced diabetes rats following treatment with triplavar in adult male Sprague-Dawley rats. 78 male Sprague-Dawley rats (n=78) weighing 200�±250 were used for the study. The study comprised of two groups i.e. a non-diabetic (A-F) comprising of six animals per group and a diabetic group (G-L) comprising of seven animals per group. Diabetes was induced in the overnight fasted rats by intraperitoneal injection of STZ (45 mg/kg body weight). The animals were euthanized on the tenth week and the kidneys were removed and prepared for examination. M. charantia illustrates significant improvement in blood glucose levels. Urinary parametric indices displayed positive outputs and enhanced protection of M. charantia. Consequently, histological observations restored kidney tissues from hyperglycemiamediated oxidative damage and efficient protection from apoptotic index.
Ugochukwu Offor is a PhD researcher in the department of clinical anatomy, University of KwaZulu-Natal Durban, South Africa. He is a member of Morphology and Andrology Group (MAG) UKZN which philosophical ethos is geared towards addressing core health issues, particularly complications arising from diabetes using sophisticated techniques for medical investigations while promoting indigenous knowledge system (IKS) that is of cutting edge significance in the Republic of South Africa. He is also a Member of Golden Key International Honours Society, an organization that recognizes specifically top 15% academic achievers globally. He was recently nominated for the International Scholars Laureate Program in Australia and China.